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Musculoskeletal Model Research Both peptides have been used separately in rodent models of tendon, ligament, and muscle disruption to study tissue-remodelling markers

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66 , 67 Restingstate functional MRI data acquired from nonspecific CLBP patients at baseline and after a manipulation for back pain intensification implicated a role of the mesocortical and mesolimbic pathways, potentially mediating the contribution of pain sensitization to pain chronification in CLBP