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We discovered that TAX6/Calcineurin serves as a key component in inhibiting GPCR signaling: while tax6 mutants were unable to generate pulsatile activity and reach exact adaptation in response to the natural stimulus diacetyl (Figs 3 and 4), their calcium dynamics following optogenetic activation was similar to wt worms (Fig 5)

In vivo models The mouse has quickly emerged as the preferred mammalian model organism in aging research

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[DOI] [PubMed] [Google Scholar] 127.Erel O., Neselioglu S