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Another chemoproteomics approach, led by Vividion Therapeutics identified a KEAP1 C151-reactive molecule which allosterically activates KEAP1, enhances the KEAP1:CUL3 interaction, and promotes NRF2 degradation [88]

No changes were evident for Lpk (encoding pyruvate kinase, which catalyses the conversion of phosphoenolpyruvate to pyruvate) or for Ppargc1a (encoding proxisome proliferator-activated receptor -1) and other mitochondrial genes involved in fatty acid oxidation (Fig
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