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Depletion leads to accumulated DNA damage and accelerated cellular aging

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Materials and methods Anti-mouse CD38 antibodies (Ab68 and Ab69) Ab68 and Ab69 antibodies UniAb clone ID337468 (Ab68) and UniAb clone ID337469 (Ab69) expressed on a silenced mouse IgG2a background are from Teneobio Inc (Newark, CA), that have been silenced to assure long half-lives, reduced immunogenicity, absence of immune effector functions, and without cytotoxic effect on CD38 positive cells