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In this review, we summarize the recent advances in the regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy and explore the prospect of combining Nrf2 inhibitors and ferroptosis inducers as a promising cancer treatment strategy

The positive effects of higher bilirubin levels are significant

Conversely, a knockdown of Bcl-2 provoked a decrease in mGSH and a concomitant oxidative stress sensitization (Wilkins et al., 2014)

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On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (El-Ansary et al., 2018