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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Ketterer B

Cuprizone-brain damage and motoric disability The used cuprizone regimen, several times higher than those regularly used in cuprizone studies (62), rapidly induced marked functional disability along with severely affected various brain areas

Long-term safety data are limited

TsaoSPNurrahmaBAKumarRWuCHYehTHChiuCCet al

A 2022 scientific review published in the National Library of Medicine confirmed that nasal delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimising systemic exposure