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Targeting critical nodes such as NLRP3, NCOA4, or ACSL4 holds promise for disrupting this cycle, offering novel strategies for precision intervention in periodontitis

These negative feedback actions of K ATP channels may be augmented by the ketogenic diet, as the presence of elevated BHB also increased the activity of K ATP channels in dentate granule neurons [27], possibly via the decrease in glycolytic ATP production

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Without them, free radicals are indeed "free" to cause oxidative stress

DHA, an omega-3 fatty acid abundant in retina) and linoleic acid (18:2) (ref