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The latter can interact with superoxide (O 2 ) to form peroxynitrite (OONO ) and hydroxyl radical (OH ) that triggers poly(ADP-ribose) polymerase 1 activation, which initiates apoptosis

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Cellular and molecular biology of aging endothelial cells

The samples were stored at 80C until being packed in dry ice and sent to Maiwei Metabolomics (Wuhan, China) for analysis
