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Topical application is limited by the stratum corneum barrier, with near-zero penetration through intact skin (Li et al., 2015)

10.13431/j.cnki.immunol.j.20130189 40 GaoJ

J.StoehlmacherJ.ZhangW.Tsao-weiD

doi: 10.1038/s41598-023-45076-5

2 Translational potential of neurotrophic factors MS, especially in the progressive disease phase, poses therapeutic challenge as current disease modifying therapies fail to address the complex crosstalk between glial cells, neurons and CNS-infiltrating cells as well as their highly dynamic functions ( Highlighting the functional dynamics of astrocytes, depletion of reactive astrocytes in early neuroinflammation increased disease severity in EAE, while depletion of reactive astrocytes during the chronic disease phase ameliorated disease pathogenesis (129, 130)