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Overman MJ, Adam L, Raghav K, Wang J, Kee B, Fogelman D, Eng C, Vilar E, Shroff R, Dasari A, Wolff R, Morris J, Karunasena E, Pisanic R, Azad N, Kopetz S

A 2022 meta-analysis of 14 controlled studies (472 patients) demonstrated microneedling with PRP produces 2.97 times higher odds of significant clinical improvement compared with microneedling alone, with 4.15 times higher patient satisfaction

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All mammalian tissues express MAT and MS, whereas BHMT is limited to the liver and kidney (Lu and Mato, 2008)
