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[33] investigated the antidepressant mechanism of CSS and found that CSS treatment significantly reversed CUMS-induced alterations in phosphorylated phosphoinositide 3-kinase (PI3K) and phosphorylated protein kinase B (AKT) expression, while decreasing glycogen synthase kinase-3beta (GSK3) expression, suggesting that the PI3K/AKT/GSK3 pathway may be involved in the antidepressant effects of CSS

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NLCs possess a solid lipid matrix containing nano-oil compartments, resulting in higher drug-loading efficiency, reduced drug leakage during storage, and provide a greater control over drug release (Duan et al., 2020