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Description
As mentioned above, many inhibitors targeting metabolic enzymes combined with cisplatin have synergistic antitumour effects (Table 2)

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[PubMed] D

29,30 The oxygenation of C20-fatty acids from both 6 and 3 PUFAs produces a wide array of eicosanoid lipid mediators, including the well-studied prostaglandins (and their autoxidation analogues, the isoprostanes), thromboxanes, hydroxy-eicosatetraenoic acids (HETEs) and leukotrienes

ROS play an important role in microbial decontamination either directly by inducing oxidative stress or indirectly by promoting pathogen clearance through a number of non-oxidative mechanisms, including autophagy, T-cell responses, and pattern recognition receptor signaling 44
