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No Phase 2 or Phase 3 RCTs have been conducted in healthy adults for cognitive enhancement

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doi: 10.1146/annurev.ph.50.030188.000315

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Since Folic Acid and Vitamin B12 play leading roles in the methylation cycle, their close-knit relationship and their impact on homocysteine has some researchers suggesting that both should be taken as supplements to prevent neural tube defects
