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While the initial substitution of stone for metal tools might be partly attributable to influence from the Pueblo and Athabascan neighbors of the Spanish in New Mexico, one must remember that stone tools continued to be used for a variety of tasks in Europe during much of the Spanish Colonial period

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However, when oxidatively stressed, these cells can be overwhelmed by oxLDL such that the excessive accumulation of lipids transforms them into foam cells, characteristic of the progression of atherosclerosis

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