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The study revealed that diabetes markedly elevated peroxide products (POX) and malondialdehyde (MDA) while reducing SOD activity in the hippocampus

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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Angle CR

(B) Functionality of the dCas9-based transcriptional repressor is demonstrated by a 5.7-fold decrease in CD81 protein expression (red histogram) compared to non-targeting gRNA controls (grey histogram), measured by geometric mean fluorescence intensity (GMFI) in the GFP+ population