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Theoretically, combining MOTS-c with a GLP-1 agonist (like semaglutide or tirzepatide) could produce synergistic effects
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235,236 In one study from Saudi Arabia, over 76% of herbal medicine users were unaware of potential herb-drug interactions, highlighting the urgent need for awareness programs and physician inquiry during patient history intake
Interestingly, it has been demonstrated that the liver clock drives glucose clearance and gluconeogenesis via signals from gut microbes [47]
