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Monomeric Ox1 (active) and Ox2 (inactive) forms of Ero1 are detected under a non-reducing condition, and the ratio of Ox1 to Ox2 indicates the Ero1L activity

A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification
Polymeric nanoparticles for mitochondria targeting mediated robust cancer therapy

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