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Amphetamine increases the concentration of dopamine in the synaptic cleft by entering the presynaptic neuron by diffusing across the neuronal membrane directly or through DAT, competitive reuptake inhibition at the transporter, and finally, the reversal of dopamine transport through DAT (i.e., dopamine efflux) [159,160,161]

Lee YI, Kim YG, Pyeon HJ, Ahn JC, Logan S, Orock A, Joo KM, Lrincz A, Dek F (2019) Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain