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Finally, key genes enriched in oligodendrocytes, including LAMP2 and PIP4K2A , which act as mediators of lysosomal and autophagosome clearance, are frequently deregulated in the brains of AD patients, implicating them in the crosstalk between AD pathology and oligodendrocyte autophagy [171]

doi:10.1002/nbm.2772

[DOI] [PubMed] [Google Scholar] Salama KHA, Al-Mutawa MM
This is when collagen synthesis effects begin showing up

doi: 10.1002/clc.20836 71