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Severe energy deficits from extreme caloric restriction can potentially suppress reproductive function

10.1124/dmd.116.070920 [DOI] [PMC free article] [PubMed] [Google Scholar] 38.Deaglio S, Aydin S, Grand MM, Vaisitti T, Bergui L, D'Arena G, et al

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While the peptide appeared well tolerated in these trials, the absence of reproducible clinical benefit meant the molecule did not progress to approval or further late-stage studies