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336 For example, in mice with myocardial ischemia-reperfusion, Drp1-mediated mitochondrial fission is upregulated, while Drp1 inhibitor can down-regulate mitochondrial fission, increase ATP, and improve cardiac function

The alternative efflux substrate of ASCT2, Serine can derive from glucose via a three enzymes pathway, i.e., phosphoglycerate dehydrogenase, phosphoserine aminotransferase, and phosphoserine phosphatase (resumed by the dotted arrow of Figure 1B)

Endocrinology and metabolism

GCLC knockout mice die within a month of birth due to the absence of hepatic GSH synthesis

PMID: 42214921 Research Square Preprint2023 Jun 14