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69 Thirdly, during the DPN, excess saturated fatty acids (SFAs) and hyperglycemia depolarize mitochondrial membranes and generate ROS, 70 which eventually produce mitochondrial dysfunction and Schwann cells (SCs) apoptosis

This process proceeds in virtually all eukaryotic cells in response to DNA damage [38]

Prodrug development has also advanced EGCGs pharmacokinetic properties by creating EGCG prodrugs through strategic chemical modifications

Other noticeable indicators may include pale or jaundiced skin, as well as a swollen or inflamed tongue

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