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Lithium medication downregulates GSK-3, the main inhibitor of the WNT/-catenin pathway

utilized a whole-genome CRISPR-based knockout screen to identify transmembrane protein 2 (TMEM2), a hyaluronidase that degraded hyaluronan in the extracellular matrix, was capable of modulating ER stress through CD44, ERK, and p38

PubMed CrossRef Preskorn SH

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GEMMs as preclinical models for testing pancreatic cancer therapies
