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In 1970, Orlowski and Meister proposed the -glutamyl cycle, which includes the synthesis, breakdown, export and import of GSH as a key process for amino acid uptake (Orlowski and Meister, 1970)

Additionally, there was a dose-dependent decrease in GSH levels in rats, indicating the production of ROS and oxidative stress

Parkinsons disease developed in 20,895 of 6,098,405 subjects (0.34%)

doi: 10.1016/j.canlet.2013.11.004 24 FreyR

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