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Activation loop of autophagy by ROS during ferroptosis Classically, ferroptosis is an iron-dependent oxidative cell death caused by ROS and has been considered autophagy-dependent ferroptosis [22, 91]

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Recent research indicates that CA plays a role in attenuating ischemic heart disease by inhibiting the NLRP3/cysteinyl aspartate specific proteinase-1(Caspase-1)/gasdermin D (GSDMD) signaling pathway

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A single strain generated with deletions for the four phospholipid hydroperoxide GPx isoforms had no difference in median lifespan, though their age-specific mortality rates and levels of lipid hydroperoxides were higher when compared to the wild-types [92]

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Diabetes mellitus is associated with increased oxidative DNA damage in sperm ( 2.2 Exogenous sources Exogenous sources of ROS primarily include physical, chemical, and lifestyle factors

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Schwann cells (SCs) in the BIPN mouse model have been shown to exhibit acute and transient ER damage

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