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AMPK is responsible for the translocation of MOTS-c to the nucleus during metabolic stress

In particular, the astrocytic ApoE (complexed with cholesterol) promotes synaptogenesis (Mauch et al., 2001), with ApoE accumulating near the synapses (Konings et al., 2021)

Growth hormone support: Certain peptides encourage the body to release its own growth hormone, which can support muscle, metabolism, and sleep quality

(5, 3135) Consistent with our study results, these studies suggest non-motor symptoms may be more likely to improve than motor symptoms when utilizing a KD, at least in the short-term
