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Because they are custom-prepared without FDA approval, insurance plans and PBMs typically do not adjudicate claims for compounded topicals

doi: 10.1212/01.WNL.0000166038.67153.9F 105

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Notably, it can potentially affect the efficacy or side-effect profile of drugs such as nitroglycerin, nitrates, and some chemotherapy agents

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase