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Why an imbalance between Phase I and II matters: Phase I detoxification processes often make a lipophilic (lipid-soluble) substance more hydrophilic for increased solubility

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[DOI] [PubMed] [Google Scholar] 35.Copur S, Demiray A, Kanbay M

The microchannels increase skin permeation more than twentyfold compared with intact skin

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