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Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]

Upon activation, these receptors exert dual functionality by inhibiting NF-B-driven inflammatory cascades and promoting favorable alterations in lipid metabolism

I developed the Rootcology MTHFR Pathways supplement, which includes betaine and B12, to contain synergistic nutrients that support homocysteine pathways, including activated forms of folate, B2, and B6

Its primary claim to fame in the research world is its cytoprotective and healing capabilities, particularly within the gastrointestinal tract