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These carbon units can bind in different oxidation states and generate different forms of tetrahydrofolate cofactors which have distinct physiological functions: 5-methyl-THF

Interestingly, a recent study has shown that testicular cancer may be treated by targeting ferroptosis [132]

Choline or Betaine (TMG) Reduces stress on the folate cycle by donating methyl groups through alternative pathways

On the one hand, it provides the material basis and one-carbon units required for the synthesis of nucleotides, proteins and phospholipids to support the rapid proliferation of tumor cells
Ferroptosis contributes to the onset and progression of AS co-depression directly or by influencing other mechanisms
