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While robust clinical trial data specific to these combinations continues to emerge, the physiological rationale and supporting evidence from component studies provide a sound basis for clinical application in appropriately selected patients

If these particular bacteria are present in high levels, they can deprive the person of choline needed for other metabolic pathways [48]

(2020) 9:R10211

doi: 10.3389/fnut.2026.1804917 Received 05 February 2026 Revised 04 March 2026 Accepted 16 March 2026 Published 31 March 2026 Volume 13 - 2026 Edited by Berenice M Romn Calleja, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico Reviewed by Anindita Banerjee, Indian Council of Medical Research (ICMR), India Venkateswararao Eeda, University of Oklahoma Health Sciences Center, United States Updates Copyright 2026 Chen, Zou, Li, Liu, Liu, Yao, Peng, Liang, Chen, Huang and Huang

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