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Thiazolidinediones therefore promote increased FA uptake and storage in subcutaneous adipose tissue, reducing levels of circulating FA and triglycerides.79 Thiazolidinediones have also been shown to stimulate specific proteins involved in glucose metabolism, including pyruvate dehydrogenase.2 Overall, by reducing FA delivery to the heart and increasing flux through glycolysis, thiazolidinediones may help to rebalance the metabolic alterations in the diabetic heart

PMID: 41270217 Adv Sci (Weinh) Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

These natural substances play crucial roles in the human body, particularly in fat metabolism and energy production