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Reversible formation of sulfenic acid mediated intramolecular disulfides is implicated as the mechanism of activation of the OxyR transcription factor and antioxidant defense against peroxides

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In addition, ferroptosis inhibition prevented A pathology, decreased lipid peroxidation and restored iron storage in human AD iPSCs-derived brain cortical organoids at day 50 of differentiation

This highlights the importance of Ruminococcus2 as a predictive and preventive factor for NAFLD risk and offers valuable insights into the potential mechanism for the gut-liver axis hypothesis

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