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The relationship between gluten sensitivity and RA development has been further reinforced by two studies that demonstrated a reduction of antibody levels towards dietary antigens, promotion of anti-inflammatory effects, and protection against atherosclerosis in RA patients who adhered to a gluten-free, vegan-based diet (Hafstrm et al

gingivalis and a depletion of commensal bacteria such as Streptococcus species

doi: 10.1016/j.neuron.2025.03.032 98 Alfaro-RodrguezAReyes-LongSRoldan-ValadezEGonzlez-TorresMBonilla-JaimeHBandalaCet al

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At the post-translational level, just as CBP/p300-mediated acetylation of Lys within the Neh1 domain increasing NRF2-dependent transcription, SIRT1 mediates Lys deacetylation, antagonizing the NRF2 signal [234]