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Experiments with fasted and calorie-restricted rats showed increased mRNA concentrations of acyl-CoA and CPT-1 in the liver, heart and kidneys compared to control animals due to upregulation of PPAR [111]

Indeed, the knockdown of SLC22A5 by siRNA-mediated inhibition could reduce carnitine intake

American Journal of Kidney Diseases (2003)

Action of L-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex
