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Analysis of application scenarios in disease research Typical applications of transgenic mice Overexpression disease models build pathological models by artificially regulating the expression levels of specific genes, providing key experimental tools for disease mechanism research and drug development

doi: 10.1097/00008571-200008000-00009

It is a major hypothesis of disease pathogenesis that causative mutations within genes might be within very similar or even identical genetic pathways

Nonetheless, several challenges must be addressed before exosome-based therapies can be clinically translated

By contrast, wzk and waaL displayed truncated LPS ( Figures 6B, C ) and elicited somewhat mitigated IL-6 secretion from challenged host cells ( Figure 5 )