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Human evidence is increasingly becoming diverse: biomarker and PK/PD studies (such as sulforaphane preparations that stimulate NRF2 and ARE gene expression in blood cells or target tissues) are the most persuasive human evidence, and only a few randomized trials and pilot studies indicate the ability to modulate oxidative-stress or inflammatory markers [271]

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For example, mitomycin C (MMC), an FDA-approved anti-cancer drug, has been found to effectively eradicate E

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