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J Physiol Pharmacol, 2013

Reported areas of investigation include angiogenesis (the formation of new blood vessels in tissue models), the modulation of inflammatory signaling, and cellular response in wound- and recovery-model systems

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It appeared unlikely that therapeutic MeCbl would have any advantage over OHCbl in the treatment of MeCbl deficiency or cobalamin deficiency in general.25 Another cellular study showed that the lysosomal reduction to cobalamin, when B 12 is supplemented as AdCbl, was 67 times slower than the reduction of MeCbl to cobalamin

Off-label use only exists after FDA approval