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BPC raises the number of GH receptors sitting on those same fibroblasts, dose-dependent and time-dependent, at the gene and the protein level (2014)

This results in rapid dissociation of bound GDP, which is then replaced by GTP, because GTP is present in the cytosol in much higher concentrations than GDP

doi: 10.1056/NEJMoa0907839 20 PfeufferSRolfesLHackertJKleinschnitzKRuckTWiendlHet al

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Expert Rev Proteom 15:113130 Tan Q, Li J, Yin HW, Wang LH, Tang WC, Zhao F, Liu XM, Zeng HH (2010) Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo