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In contrast, creatine doesnt seem to support that or similar mechanisms

Pellatt, AJ, Maddalena, G, Bent, AH, Parseghian, C, Huey, RW, Raghav, KS, Morris, VK, Overman, MJ, Morelli, MP, Willis, JA, Le, PH, Shen, JY, Alfaro, KD, Aziz, KE, Kell, R, Sun, R, Kopetz, S , Dasari, NV

10.2 Decoding metabolic heterogeneity for precision targeting While single-cell technologies have revealed metabolic diversity in neurons and glia, most studies remain static

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Later on, as the total body uric acid decreases, this will generally no longer be needed
