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Instead, the P24-P23 protein complex, which can bind to Sec24D, acts as a cargo receptor to mediate the export of GPI-anchored proteins like CD59 or the folate receptor (Levental et al., 2010a), there is some suggestion that such GPI-anchor rich exit sites may be related to lipid raft domains on the ER membrane ( Evidence for Lipid Domains at Inter-Organelle Contact Sites Mitochondria-associate membranes (MAMs) are ER subdomains that play crucial roles in inter-organellar crosstalk between ER and mitochondria required for the homeostasis of both organelles

[DOI] [PubMed] [Google Scholar] 88.Hiramatsu A, Aikata H, Uchikawa S, Ohya K, Kodama K, Nishida Y, Daijo K, Osawa M, Teraoka Y, Honda F, et al

Cheng AT

Modi ME, Young LJ (2011)

Drug delivery complexities are further exacerbated by physicochemical barriers, particularly for compounds targeting organelle-specific lipid pools, where biological membrane permeability and intracellular pH gradients restrict effective biodistribution