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Abbreviations AAT aspartate aminotransferase Ala alanine ALAT alanine aminotransferase APOE apolipoprotein E Asp aspartate BCAA branchedchain amino acid BCAT branchedchain amino acid aminotransferase BCKA branchedchain keto acid CaMKII Ca 2+ /calmodulindependent protein kinase II alpha EAAT excitatory amino acid transporter GABA aminobutyric acid GABAT GABA transaminase GAD glutamate decarboxylase GAT GABA transporter GDH glutamate dehydrogenase GHB hydroxybutyrate GLAST glutamate aspartate transporter 1 GLT1 glutamate transporter1 Glu glutamate GS glutamine synthetase iPSC induced pluripotent stem cell LAT Ltype amino acid transporter MAS malateaspartate shuttle NMR nuclear magnetic resonance OAA oxaloacetate PAG phosphateactivated glutaminase PC pyruvate carboxylase PDH pyruvate dehydrogenase Pyr pyruvate ROS reactive oxygen species SLC solute carrier SNAT sodiumcoupled neutral amino acid transporter SSADH succinic semialdehyde dehydrogenase TCA tricarboxylic acid (cycle) KG ketoglutarate 1

The most common one is primarily associated with the activity of -glutamyl transpeptidase (GGT) (Figure 2)

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