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Blood (2010) 116:421222

Extensive long-term testing has administered AOD-9604 continuously to observe sustained safety profiles, noting it does not induce anti-AOD-9604 antibodies, alter IGF-1 levels, or negatively impact overall insulin sensitivity over time. Evidence Limitations While AOD-9604 has a highly favorable safety profiledemonstrating no adverse effects on blood sugar, IGF-1, or cardiovascular markers in in vivo and in vitro modelsit is not approved by the FDA for the treatment of obesity, weight loss, or joint repair