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10.1016/j.foodres.2011.06.007 Food Res
The methionine cycle metabolites are further reduced compounding the effects of trisomy 21

M., Pouyssegur, J

So it can be converted into intermediates that are used to make energy by the mitochondria

For instance, Artemisinin generates ROS and induces apoptosis while weakly inhibiting GPX4 to trigger mild ferroptosis
