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CPT II deficiency (which most often presents with exercise intolerance and myoglobinuria and is discussed below) [130]

Even partial glutathione depletion has been shown to impair immune function and increase our susceptibility to free radical damage

While essential for some physiological processes, an imbalance between free radical production and the bodys ability to manage these reactive species leads to oxidative stress

& Jaisser, F

Reversal of drug resistance and recurrence by enzyme inactivation Disulfiram forms chemical bridges with key cysteine residues found near the active sites of enzymes and proteins such as ALDH, MGMT, PHGDH, and P-gp