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doi: 10.2174/1871527314666150821103306 125 NguyenV

Preclinical studies of stem-cell based treatments for Parkinsons and disease modeling efforts iPSCs and 3D brain organoids have significantly advanced our understanding of PD pathophysiology and assisted in drug development by allowing us to replicate the specific mutations commonly found in familial PD (fPD), including those in -synuclein [74, 75]

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93 96 Using a statistical analysis of the de novo, likely gene-disruptive mutations, upward of 50% of ASD is postulated to be caused by spontaneous mutations