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Nrf2 is the main regulator of mammalian cell redox response and plays a vital role in maintaining cellular homeostasis (106, 107)

If an antioxidant is not present in sufficient quantity to neutralize ROS, oxidation of biomolecules, like lipid peroxidation, protein damage (carbonylation of aminoalkanoic acid residues), oxidation of single DNA and RNA nucleotides, enzyme inhibition, and activation of apoptosis, will occur (Gill and Tuteja, 2010)

Recently, six additional peptides in the same region of mtDNA as humanin ( i.e

Materials and methods Chemicals Hexadecyl trimethyl ammonium bromide (CTAB), triethanolamine (TEA, 99%), tetraethyl orthosilicate (TEOS), anhydrous tetrahydrofuran (THF), and bis (triethoxysilyl propyl) disulfide (BTES) were purchased from Sigma-Aldrich

10.1128/iai.68.8.4624-4630.2000 90 McKellarQ