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The core idea is that to maintain their stemness and survival, CSCs exhibit unique iron metabolism dependence and an active antioxidant system
Another study suggested that artesunate ameliorated LPS-mediated release of apoptotic proteins NLRP1, CASP-3, ASC, and CASP-1 in NR8383 cells by regulating SIRT1 expression in vivo (Liu Z
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Meanwhile, oxidative stress can alter the activity of enzymes involved in lipid metabolism, such as lipoprotein lipase (LpL), disrupting the balance between lipid synthesis and breakdown (30)
