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doi: 10.1152/physiolgenomics.00194.2006

Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

If you experience persistent headaches, fatigue, mood changes, and other symptoms that dont resolve within a few days, contact your prescribing clinician immediately to assess your condition and prevent possible complications

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J Clin Endocrinol Metab 100:31123117