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Without sufficient antioxidant defenses, toxins and oxidative stress can accumulate

Elevated 12-LOX expressions and activity are evident in both human diabetic specimens and experimental diabetic mice, as well as in oxygen-induced retinopathy, while genetic or pharmacologic LOX inhibition reduces neovascularization and barrier breakdown ( CYP450 and soluble epoxide hydrolase (sEH) The cytochrome P450 lipid axis (Figure 2) contributes to DR, but the directionality of benefit can be context dependent

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Zhou, D., Chen, N., Huang, S., Song, C

[DOI] [PMC free article] [PubMed] [Google Scholar] 654.Duncan A, Yacoubian C, Watson N, Morrison I